(주) 드림셀-생명공학 실험실용 시약, 기기, 소모품

홈 > 제품정보 > 시약 > 해외 공식 대리점 > [io1019] ioSkeletal Myocytes DMD Del Ex52/Y

제품코드 : io1019

제품정보 : ioSkeletal Myocytes DMD Del Ex52/Y

Human iPSC-derived Duchenne muscular dystrophy model ioSkeletal Myocytes DMD Exon 52 Deletion are opti‑ox deterministically programmed skeletal myocytes carrying a genetically engineered hemizygous deletion in exon 52 of the DMD gene encoding the dystrophin protein. These cells offer a rapidly maturing, consistent, scalable system to study Duchenne muscular dystrophy in a functional human cell model. Dystrophin restoration has been demonstrated by ASO-mediated exon skipping. Additionally, the disease model cells form 3D muscle cell bundles that show weaker contraction and fatigue compared to the wild-type control. A related disease model is available with a hemizygous exon 44 deletion and both can be used alongside their genetically matched control, ioSkeletal Myocytes. Applications: Muscle and neuromuscular research, Disease modelling, Contractility assays, 3D muscle tissue engineering

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