(주) 드림셀-생명공학 실험실용 시약, 기기, 소모품

홈 > 제품정보 > 시약 > 해외 공식 대리점 > [io1029] ioMicroglia Female

제품코드 : io1029

제품정보 : ioMicroglia Female

Female human iPSC donor-derived microglia ioMicroglia (io1029) are female donor-derived human microglial cells from iPSC, deterministically programmed using opti-ox technology. Within 10 days post-revival, ioMicroglia are ready for experimentation, expressing (>90%) key microglia markers, including P2RY12, IBA1, TREM2, CX3CR1, CD11b, CD45, and CD14. Female donor-derived ioMicroglia recapitulate key human microglia functions with lot-to-lot consistency, including mediating an inflammatory response, disposal of unwanted materials, and carrying out immune surveillance. In addition, these cells can be co-cultured with ioGlutamatergic Neurons (io1001) to gain insights into complex intercellular interactions. Female donor-derived ioMicroglia provide a functional, consistent, rapid, and easy-to-use hiPSC-based model for neurodegenerative disease research and drug development. These cells can be used in conjunction with our male iPSC donor-derived ioMicroglia (io1021) and related disease models for Alzheimer's to study the effect of donor and sex-related differences and disease relevant mutations on microglia phenotype, functionality, and drug response. Applications: Neurodegenerative disease modelling, Drug discovery and development, Neuroinflammation modelling, Phagocytosis assays, Cytokine response assays, Co-culture studies, Transcriptome analysis

인류의 건강과 생명공학 발전을 위해 봉사하는 기업 드림셀