(주) 드림셀-생명공학 실험실용 시약, 기기, 소모품

홈 > 제품정보 > 시약 > 해외 공식 대리점 > [io1032] ioMicroglia APOE 4/4 C112R/C112R (CL69)

제품코드 : io1032

제품정보 : ioMicroglia APOE 4/4 C112R/C112R (CL69)

Human iPSC-derived Alzheimer's disease model ioMicroglia APOE 4/4 are opti-ox deterministically programmed microglia carrying a genetically engineered homozygous C112R mutation in the APOE gene, converting the wild-type APOE3 allele to APOE4, encoding the apolipoprotein E4. The APOE4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). These cells offer a functional, rapidly maturing, and disease relevant system to study the role of APOE4 in late-onset AD, alongside a genetically matched wild-type control. Two clones are available (Clone 83 available on request), all genetically matched to the wild type control, ioMicroglia. The disease model cells and the wild-type control offer a physiologically relevant model to investigate the effect of APOE4 on cellular and molecular mechanisms and function in late-onset AD. Applications: Alzheimer's disease modelling, Drug discovery and development, Neuroinflammation modelling, Phagocytosis assays, Cytokine response assays, Co-culture studies

인류의 건강과 생명공학 발전을 위해 봉사하는 기업 드림셀