(주) 드림셀-생명공학 실험실용 시약, 기기, 소모품

홈 > 제품정보 > 시약 > 해외 공식 대리점 > [io1038] ioMicroglia TREM2 R47H/WT (CL86)

제품코드 : io1038

제품정보 : ioMicroglia TREM2 R47H/WT (CL86)

Human iPSC-derived Alzheimer's disease model ioMicroglia TREM2 R47H/WT are opti-ox deterministically programmed microglia carrying a genetically engineered heterozygous R47H mutation in the TREM2 gene encoding the triggering receptor expressed on myeloid cells 2 protein. The TREM2 R47H mutation has been linked with increased risk of late-onset Alzheimer's disease (AD). These cells offer a functional, rapidly maturing, and disease relevant system to study the role of the TREM2 R47H mutation in late-onset AD, alongside a genetically matched wild-type control. Related disease model cells are available with a homozygous TREM2 R47H mutation, and both can be used alongside their genetically matched control, ioMicroglia. The disease model cells and the wild-type control offer a physiologically relevant model to investigate the impact of the TREM2 R47H mutation on cellular and molecular mechanisms and function in late-onset AD. Applications: Alzheimer's disease modelling, Drug discovery and development, Neuroinflammation modelling, Phagocytosis assays, Cytokine response assays, Co-culture studies

인류의 건강과 생명공학 발전을 위해 봉사하는 기업 드림셀