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홈 > 제품정보 > 시약 > 해외 공식 대리점 > [io1050] ioMotor Neurons TDP-43 M337V/WT

제품코드 : io1050

제품정보 : ioMotor Neurons TDP-43 M337V/WT

Human iPSC-derived ALS and FTD disease model Within days, cells convert to a defined and scalable genetically matched system to study amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ioMotor Neurons TDP‑43 M337V/WT are opti‑ox deterministically programmed motor neurons carrying a genetically engineered heterozygous M337V mutation in the TARDBP gene, encoding TAR DNA binding protein 43 (TDP‑43). Related disease model cells are available with a homozygous TDP‑43 M337V/M337V mutation, and both can be used alongside their genetically matched control, ioMotor Neurons. Additional disease models are available in ioGlutamatergic Neurons with mutations in TDP‑43 and MAPT, creating a comprehensive toolkit to study the genetic and pathological overlap between ALS and FTD. Applications: Neurodegeneration research, ALS & FTD disease modelling, Electrophysiological analysis, Drug development & discovery, Neuromuscular research, Neurotoxicology

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