홈> 제품정보 > 시약 > 해외 공식 대리점 >[io1055] ioMotor Neurons FUS P525L/WT (CL71)
[io1055] ioMotor Neurons FUS P525L/WT (CL71)
제품코드 : io1055
제품정보 : ioMotor Neurons FUS P525L/WT (CL71)
Human iPSC-derived ALS disease model
ioMotor Neurons FUS P525L/WT are opti‑ox deterministically programmed ioMotor Neurons carrying a genetically engineered heterozygous mutation in the FUS gene encoding the Fused in Sarcoma protein.
Within days, cells convert to a defined and scalable genetically matched system for investigating the molecular and cellular significance of a heterozygous P525L mutation in ALS.
Related disease model cells are available with a homozygous FUS P525L/P525L mutation, and both can be used alongside their genetically matched control, ioMotor Neurons.
Additional disease models are available in ioGlutamatergic Neurons with mutations in TDP‑43 and MAPT, creating a comprehensive toolkit to study the genetic and pathological overlap between ALS and FTD.
Applications: Neurodegeneration research, ALS disease modelling, Electrophysiological analysis, Drug development & discovery, Neuromuscular research, Neurotoxicology