(주) 드림셀-생명공학 실험실용 시약, 기기, 소모품

홈 > 제품정보 > 시약 > 해외 공식 대리점 > [io1061] ioGlutamatergic Neurons APP KM670/671NL/WT (CLE4)

제품코드 : io1061

제품정보 : ioGlutamatergic Neurons APP KM670/671NL/WT (CLE4)

Human iPSC-derived Alzheimer's disease model A rapidly maturing, physiologically relevant, functional system for investigating the role of the APP Swedish mutation in early-onset Alzheimer's disease (AD). This in vitro disease cell model recapitulates an overall increase in the production of amyloid beta peptides, as observed in AD. ioGlutamatergic Neurons APP KM670/671NL / WT are opti‑ox deterministically programmed excitatory neurons carrying a genetically engineered heterozygous double mutation in the APP gene encoding amyloid precursor protein. This disease model is part of an Alzheimer's disease panel of human iPSC-derived cells that can be incorporated into translational research and drug discovery workflows. Two additional clones for the APP KM670/671NL het mutation are available for scientists who wish to repeat their experiments in multiple independent clones, please enquire. All disease models are genetically matched to the wild-type control, ioGlutamatergic Neurons. Additional mutations in the AD panel include homozygous APP KM670/671NL, and heterozygous and homozygous APP V717I and PSEN1 M146L, alongside AD-relevant mutations in ioGABAergic Neurons and ioMicroglia. Applications: Alzheimer's disease research, Drug discovery and development, Disease modelling

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