(주) 드림셀-생명공학 실험실용 시약, 기기, 소모품

홈 > 제품정보 > 시약 > 해외 공식 대리점 > [io1069] ioGlutamatergic Neurons PSEN1 M146L/M146L (CL15)

제품코드 : io1069

제품정보 : ioGlutamatergic Neurons PSEN1 M146L/M146L (CL15)

Human iPSC-derived Alzheimer's disease model A rapidly maturing, physiologically relevant, functional system for investigating the role of the homozygous PSEN1 M146L mutation in early-onset Alzheimer's disease (AD). This in vitro disease cell model recapitulates an increase in the amyloid beta peptide ratios observed in AD patients. ioGlutamatergic Neurons PSEN1 M146L/M146L are opti‑ox deterministically programmed excitatory neurons carrying a genetically engineered homozygous M146L mutation in the PSEN1 gene encoding presenilin 1 protein. This disease model is part of an Alzheimer's disease panel of human iPSC-derived cells that can be incorporated into translational research and drug discovery workflows. Two additional clones for the PSEN1 M146L/M146L mutation are available for scientists who wish to repeat their experiments in multiple independent clones, please enquire. All disease models are genetically matched to the wild-type control, ioGlutamatergic Neurons. Additional mutations in the AD panel include heterozygous PSEN1 M146L, heterozygous and homozygous APP KM670/671NL and APP V717I. Applications: Alzheimer's disease research, Drug discovery and development, Disease modelling

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