(주) 드림셀-생명공학 실험실용 시약, 기기, 소모품

홈 > 제품정보 > 시약 > 해외 공식 대리점 > [io1072] ioGlutamatergic Neurons PSEN1 M146L/WT (CL8)

제품코드 : io1072

제품정보 : ioGlutamatergic Neurons PSEN1 M146L/WT (CL8)

Human iPSC-derived Alzheimer's disease model A rapidly maturing, physiologically relevant, functional system for investigating the role of the heterozygous PSEN1 M146L mutation in early-onset Alzheimer's disease (AD). This in vitro disease cell model recapitulates an increase in the amyloid beta peptide ratios observed in AD patients. ioGlutamatergic Neurons PSEN1 M146L/WT are opti‑ox deterministically programmed human excitatory neurons carrying a genetically engineered heterozygous M146L mutation in the PSEN1 gene encoding presenilin 1 protein. This disease model is part of an Alzheimer's disease panel of human iPSC-derived cells that can be incorporated into translational research and drug discovery workflows. Two additional clones for the PSEN1 M146L/WT mutation are available for scientists who wish to repeat their experiments in multiple independent clones, please enquire. All disease models are genetically matched to the wild-type control, ioGlutamatergic Neurons. Additional mutations in the AD panel include homozygous PSEN1 M146L, heterozygous and homozygous APP KM670/671NL and APP V717I. Applications: Alzheimer's disease research, Drug discovery and development, Disease modelling

인류의 건강과 생명공학 발전을 위해 봉사하는 기업 드림셀