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홈 > 제품정보 > 시약 > 해외 공식 대리점 > [io1084] ioGABAergic Neurons APP V717I/WT (CL65)

제품코드 : io1084

제품정보 : ioGABAergic Neurons APP V717I/WT (CL65)

Human iPSC-derived Alzheimer's disease model ioGABAergic Neurons APP V717I/WT are opti-ox deterministically programmed GABAergic neurons, also known as inhibitory interneurons, carrying a genetically engineered heterozygous V717I (London) mutation in the APP gene encoding the amyloid precursor protein. This mutation is linked to familial early-onset Alzheimer's disease (AD). These cells offer a functional, rapidly maturing, and disease relevant system in inhibitory neurons to study the role of the APP V717I (London) mutation in early-onset AD, alongside a genetically matched (isogenic) wild-type control. Two clones are available, all genetically matched to the wild type control (ioGABAergic Neurons). The disease model cells and the wild-type control offer a physiologically relevant model to investigate the impact of the APP V717I mutation on cellular and molecular mechanisms and function in early-onset AD. Applications: Alzheimer's disease modelling, Drug discovery and development, MEA analysis, Co-culture studies, ASO screening

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