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홈 > 제품정보 > 시약 > 해외 공식 대리점 > [io6019] ioMotor Neurons TDP‑43 A382T/WT

제품코드 : io6019

제품정보 : ioMotor Neurons TDP‑43 A382T/WT

Human iPSC-derived ALS and FTD disease model Within days, cells convert to a defined and scalable genetically matched system to study amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ioMotor Neurons TDP‑43 A382T/WT are opti‑ox deterministically programmed motor neurons carrying a genetically engineered heterozygous A382T mutation in the TARDBP gene, encoding TAR DNA binding protein 43 (TDP‑43). Related ioMotor Neurons disease model cells are available with a homozygous TDP‑43 M337V/M337V mutation, a heterozygous TDP-43 M337V/WT mutation or a heterozygous TDP-43 N352S/WT mutation. Which can all be used alongside their genetically matched control, ioMotor Neurons. Additional disease models are available in ioGlutamatergic Neurons with mutations in TDP‑43 and MAPT, creating a comprehensive toolkit to study the genetic and pathological overlap between ALS and FTD. Applications: Neurodegeneration research, ALS & FTD disease modelling, Electrophysiological analysis, Drug development & discovery, Neuromuscular research, Neurotoxicology

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