(주) 드림셀-생명공학 실험실용 시약, 기기, 소모품

홈 > 제품정보 > 시약 > 해외 공식 대리점 > [ioEA1005] ioGlutamatergic Neurons TDP-43 M337V/M337V

제품코드 : ioEA1005

제품정보 : ioGlutamatergic Neurons TDP-43 M337V/M337V

Human iPSC-derived ALS and FTD disease model A rapidly maturing, consistent and scalable system to study amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ioGlutamatergic Neurons TDP‑43 M337V/M337V are opti‑ox deterministically programmed excitatory neurons carrying a genetically engineered homozygous M337V mutation in the TARDBP gene, encoding TAR DNA binding protein 43 (TDP‑43). The disease model cells show a phenotype of reduced neuronal activity compared to the genetically matched control detected by microelectrode array (MEA) analysis. Related disease model cells are available with a heterozygous TDP‑43 M337V mutation, and both can be used alongside their genetically matched (isogenic) control, ioGlutamatergic Neurons. Applications: FTD and ALS research, Drug discovery and development, Disease modelling, High-throughput screening, Electrophysiological assays (MEA), Co-culture studies

인류의 건강과 생명공학 발전을 위해 봉사하는 기업 드림셀