제품상세

Human iPSC-derived ALS and FTD disease model 

A rapidly maturing, consistent and scalable system to study amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

ioGlutamatergic Neurons TDP‑43 M337V/WT are opti‑ox deterministically programmed excitatory neurons carrying a genetically engineered heterozygous M337V mutation in the TARDBP gene, encoding TAR DNA binding protein 43 (TDP‑43). 

Related disease model cells are available with a homozygous TDP‑43 M337V mutation, and both can be used alongside their genetically matched (isogenic) control, ioGlutamatergic Neurons.

Applications: FTD and ALS research, Drug discovery and development, Disease modelling, High-throughput screening, Electrophysiological assays (MEA), Co-culture studies